The 1st LIME International Conference

Tuesday, May 2013 19:30-20:30　
Holiday Inn Seattle Emerald room

Prof. James V. Jester
[Ophthalmology　School of Medicine University of California, Irvine]

“The Effects of Age and Evaporative Stress on Meibomian Gland Function.”

The 2nd LIME International Conference

Friday, April 4,2014 18:00-20:00　
The University of Tokyo, Reception Room

Prof. Shizuya Saika
[Department of Ophthalmology, Wakayama Medical University]

“Growth factor signaling in embryonic eyelid morphogenesis.”

Prof. Choun-Ki Joo
[Department of Ophthalmology, College of Medicine, The Catholic University of Korea]

“3D imaging of Meibomian glands”

The 3rd LIME International Conference

Saturday,November 22,2014 15:00-17:00
The University of Tokyo, 15F meeting room

Dr. Tohru Sakimoto
[Nihon University Itabashi Hospital]

“Fundamental mechanisms of ocular surface inflammation”

Prof. Kyoung Yul Seo
[Yonsei University, Seoul, South Korea]

“Inflammatory cytokines related to MGD”

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The 4th LIME International Conference

Wednesday, May 4,2016 19:30
Seattle, USA

Opening Remarks

Reiko Arita, Itoh Clinic / LIME, Japan

I. Mini-symposium “Meibomian Gland”

– Organizers

Naoyuki Morishige(Yamaguchi Univ.), Shizuka Koh(Osaka Univ.),
Motoko Kawashima(Keio Univ.), Rika Shirakawa(Univ. of Tokyo)

Topic / Speaker	Moderator
New insights of lipid layer and meibomian glands. Reiko Arita(Itoh Clinic / LIME, Japan)	Choun-Ki Joo (Catholic Univ. of Korea, S. Korea)
The relationship between Morphology and Function of the meibomian glands. Jong Suk Song(Korea Univ., S. Korea)	Kyoung Yul Seo (Yonsei Univ. Hospital, S. Korea)
The clinical application of in vivo confocal microscopy of the meibomian glands. Edoardo Villani(Univ. of Milan, Italy)	James V. Jester (Univ. of Calif. Irvine, USA)
Nonobvious MGD. Caroline Blackie(TearScience, USA)	Jerry Paugh (Southern Calif. College of Optometry, USA)

II. Integral Discussion “Diagnostic criteria for MGD in each country”

– Organizers

Shizuya Saika (Wakayama Medical Univ.), Reiko Arita (Itoh Clinic)

III. Open Discussion with Dinner

• Program
• Photo gallery

The 5th LIME International Conference

Monday, September 26, 2016Tokyo,Japan

Prof. Eric Knop
[Center for Anatomy,Charite – Universitätsmedizin Berlin, Germany]

“A New Holistic Concept on the PATHOPHYSIOLOGY OF DRY EYE DISEASE”

Photo gallery

The 6th LIME International Meeting

Tuesday, May 9, 2017Baltimore, USA

Opening Remarks

Dr.Reiko Arita (Representative Board Member, LIME Working Group)

Greetings from TearScience

Thomas Fry (Vice President, International, TearScience)

Introduction speake

Dr. Reiko Arita

Plenary Lecture

Dr. Donald R. Korb (Korb Associates, Korb Research)
“MGD – The center of the dry eye universe: 1980 – 2017”

Discussion with Dr. Korb

Dinner

Greetings from TearScience

Clyde F. Ito (Asia Pacific Business Development Manager, TearScience)

Closing Remarks

Dr.Naoyuki Morishige (Board Member, LIME Working Group)

• More info
• Program
• Photo gallery

The 7th LIME international meeting

Sunday, Aplil 29, 2018Hawaii, USA

Opening Remarks

Reiko Arita (Representative LIME Board Meeting)

Sponsor Company Greetings

Mr. Serita (KOWA). Mr. Sato (Lumenis Japan)

1. Clinical Research in MGD and Meibomian gland

– Moderator

Dr. Jennifer Craig(The University of Auckland, New Zealand)

Topic	Speaker
Healthcare delivery in MGD and blepharitis.	Dr. Louis MG. Tong (Singapore National Eye Center, Singapore)
The efficacy of IPL (M22) treatment on refractory MGD – a multi-center study-.	Dr. Reiko Arita (Itoh clinic, Japan)
Understandings of lipid profile with DR-1α tear interferometry.	Dr. Kyoung Yul Seo (Yonsei University College of Medicine, South Korea)

2. Basic Research in Meibomian gland

– Moderator

Dr. Choun-Ki Joo(St.Catholic University of Medicine, South Korea)
Dr. Naoyuki Morishige(Ohshima Eye Hospital, Japan)

Topic	Speaker
Combined Optical Coherence Tomography and Interferometry for Imaging the Tear Film.	Dr. William Ngo (University of Alabama at Birmingham, U.S.)
Notch signaling in MGs and its therapeutic potential.	Dr. Ali R. Djalilian (University of Illinois Hospital, U.S.)
Meibogenesis – biosynthesis of lipids in the Meibomian gland from the genomic and lipidomic points of view	Dr. Igor Butovich (University of Texas Southwestern Medical Center, Dallas, U.S.)
PPAR gamma regulation of Meibocyte Differentiation.	Dr. James V. Jester (University of California, Irvine, U.S.)

Group photo

Total Discussion and Buffet

Closing remarks

• More info
• Program
• Photo Gallery

The 8th LIME international meeting

Tuesday, April 30, 2019Vancouver,Canada

– Facilitator

Osama Ibrahim (Department of Ophthalmology,Tokyo Dental College, Japan)

Opening remarks

Reiko Arita (Representative LIME Board Meeting)

Sponsor Company Greetings

Sean Clark (Alcon Japan Ltd.)

1.Presentations from LIME international members

Moderator:
Dr. Louis MG. Tong (Singapore National Eye Center, Singapore)

Topic	Speaker
Meibography	Dr. Tor Paaske Utheim (Univesrity of Oslo, Norway)

Moderator:
Dr. Eduardo Villani(University of Milan, Italy)

Topic	Speaker
MGD and Dry eye are similar, but different; based on a population-based study in Japan (Hirado-Takushima Study)	Dr. Reiko Arita (Itoh clinic, Japan)

Moderator:
Dr. Shizuka Koh(Osaka University, Japan)

Topic	Speaker
Mechanical and eyeliner effect on meibomian glands	Dr. Jerry Paugh (Ketchum University, U.S.)

2.Key Note Lectures

Moderator:
Dr. Jennifer Craig(The University of Auckland, New Zealand)
Dr. Kyoung Yul Seo(Yonsei University, South Korea)

Topic	Speaker
Pharmacological effects on meibocyte differentiation	Dr. Friedrich Paulsen (Friedrich Alexander University of Erlangen-Nürnberg, Germany)
Ménage à trois: Sex, sex steroids and meibomian gland dysfunction	Dr. David A. Sullivan (Schepens Eye Research Institute, Harvard Medical School, U.S.)

Group Photo

Total Discussion and Buffet

Closing remarks

• More info
• Program
• Photo Gallery

The 9th LIME International Meeting

Monday, May 6, 2024Seattle,U.S.A

Opening Remarks & my current recommendation for MGD treatment

Dr. Reiko Arita (LIME working group, Itoh Clinic, Japan)

■Organizers

Topic / Speaker	Moderator
“Etiology of dry eye with decreased tear stability focusing on a neurological perspective” Dr. Minako Kaido (Tsubota Laboratory, Wada Eye Clinic, Japan)	Prof. Kyung-Sun Na (St. Catholic Univ, South Korea)
“Staging-oriented meibomian gland dysfunction treatment” Prof. Kyoung-Yul Seo (Yonsei Univ, South Korea)	Dr. Shima Fukuoka (The University of Tokyo, Japan)
“The Safety and Efficacy of Lotilaner in treatment of Demodex Blepharitis” Dr. Kavita Dhamdhere(Tarsus, USA)	Prof. Yuichi Hori (Toho University Omori Medical Center, Japan) Prof. Jong-Suk Song (Korea Univ, South Korea)
“The growing need for validated ocular surface biomarkers: the role of imaging” Dr. Edoardo Villani(Univ. of Milan, Italy)	Prof. James V Jester (Univ of California, USA)
“A novel interferometric device for measurement of tear film lipid layer thickness in mice” Prof. Hosik Hwang (St. Catholic Univ, South Korea)	Prof. James V Jester (Univ of California, USA)

Closing Remarks

Dr. Reiko Arita (LIME working group, Itoh Clinic, Japan)

Group photo

• More Info
• Program
• Photo Gallery

First LIME – KMOS Joint Meeting

Saturday, April 28, 2018Hawaii

1. Greetings

Dr. Arita and Dr. Song
Santen company

2. First session : Hot topics on MGD

– Moderator : Dr. Kawashima and Dr. Jun RM

One presentation from LIME : Dr. Suzuki
One presentation from KMOS : Dr. Hwang HS

3. Sponsor session

– Moderator : Dr. Kawashima and Dr. Jun RM

“Efficacy of Diquas on lipid layer of tear film” : Dr. Fukuoka

4. Plenary lecture

– Moderator : Dr. Arita and Dr. Song

Dr. Jennifer Craig
Discussion

5. Debate session

Dr. Seo and Dr. Morishige

“Definition, diagnostic criteria, classification and management of MGD in each country”

One presentation from KMOS : Dr. Song
One presentation from LIME : Dr. Arita
Discussion

5. Group photo and Dinner

6. Self-introduction to LIME and KMOS members

– Moderator : Dr. Shirakawa and Dr. Eom Y

7. Swimming

• More info
• Program

2nd LIME-KMOS Joint Meeting

Saturday, April 27, 2019Vancouver,Canada

1.Opening Remarks

Reiko Arita, Itoh Clinic, Japan

2.Welcome Address

Santen

Facilitator

Osama Ibrahim, LIME, Japan

4.Progress of international collaborative study

Jong Suk Song, Korea University, Korea

5.Presentation from LIME & Discussion

Results from population-based study in Takushima island

Reiko Arita, Itoh Clinic, Japan

6.Presentation from KMOS & Discussion

EPA activates PPARγ signaling leading to lipid synthesis and autophagy in hMGEC

Sun Woong Kim, Yonsei University, Korea

7.Key note lecture & Discussion

Diagnostic classification of tear dysfunction
– the similarities and differences between MGD, conjunctivochalasis and aqueous deficiency-

Stephen C. Pflugfelder, Baylor College, US

8.Group Photo & Dinner

• More info
• Program
• Photo Gallery

4th LIME-KMOS Joint Meeting

Sunday, May 5, 2024Seattle,U.S.A

1. Greetings

Dr. Reiko Arita and Dr. Hosik Hwang
Kukje company

2. First session/Hot topics on MGD

■Moderator: Dr. Shima Fukuoka and Dr. Jong Suk Song

Topic	Speaker
Quantitative comparison of meibomian glands measured by in vivo and ex vivo meibography in BALB/c mice	Ho Sik Hwang
Effects of Blinking Exercises on Palpebral Fissure Height and Tear Film Parameters	Reiko Arita

2. Special lectures/Hot topics on MGD

■Moderator: Dr. Reiko Arita and Dr. Hosik Hwang

Topic	Speaker
To be announced	James Jester
To be announced	Jeongsub Kim

3. Coffee break

4. Sponsor session

■Moderator: Dr. Minako Kaido and Dr. Hong Kyun Kim

Topic	Speaker
Comparing two mucin secreagogue for treatment of dry eye disease	Dr. Sunwoong Kim

5. Group photo

6. Self-introduction to LIME and KMOS members

7. Dinner

• More Info
• Program
• Photo Gallery